Associate ScientistII/ III
Lexington, MA
Date Posted:26-Aug-2025
Work Type:On-Site
Job Number:463661
Job Description
Job Title: Associate ScientistII/ III
Location: 33 Hayden Ave, Lexington, MA, 02421, Onsite(5days/Wk)
Duration: 1 Year
Top Skills Per Mgr:
1. Human iPSC-derived neuron culture experience
2. Gene perturbations using siRNA and/or CRISPR
3. Cell-based molecular and biochemical assays including 1) immunocytochemistry, 2) qPCR, 3) ELISA, 4) micro-electrode array (MEA), and 5) fluorescence microscopy (at least 2-3 of these 5 skillsets).
Job Description:
Position Summary:
We are seeking a highly motivated and detail-oriented scientist to join our Humanized In Vitro Model Development team. The successful candidate will contribute to the development of human iPSC-derived neuronal models and assays to support drug discovery and translational research. This is an exciting opportunity to work at the forefront of human-relevant neuroscience in a collaborative and innovative environment.
Key Responsibilities:
Qualifications:
Preferred Skills:
Location: 33 Hayden Ave, Lexington, MA, 02421, Onsite(5days/Wk)
Duration: 1 Year
Top Skills Per Mgr:
1. Human iPSC-derived neuron culture experience
2. Gene perturbations using siRNA and/or CRISPR
3. Cell-based molecular and biochemical assays including 1) immunocytochemistry, 2) qPCR, 3) ELISA, 4) micro-electrode array (MEA), and 5) fluorescence microscopy (at least 2-3 of these 5 skillsets).
Job Description:
Position Summary:
We are seeking a highly motivated and detail-oriented scientist to join our Humanized In Vitro Model Development team. The successful candidate will contribute to the development of human iPSC-derived neuronal models and assays to support drug discovery and translational research. This is an exciting opportunity to work at the forefront of human-relevant neuroscience in a collaborative and innovative environment.
Key Responsibilities:
- Culture, differentiate, and maintain human iPSC-derived neurons.
- Perform routine cell-based and molecular assays including immunocytochemistry, qPCR, ELISA, MEA, luciferase, western blot, and fluorescence microscopy.
- Conduct functional gene perturbations and pharmacological interventions.
- Support assay development and optimization for phenotypic screening and mechanistic studies.
- Analyze and interpret experimental data, maintain accurate records, and present findings in team meetings.
- Collaborate cross-functionally with scientists in different units.
- Contribute to protocol development, SOP documentation, and continuous improvement initiatives.
Qualifications:
- Bachelor’s or Master’s degree in Neuroscience, Cell Biology, Stem Cell Biology, or a related field.
- LEVEL II - Minimum of 2 years of hands-on experience with human iPSC-derived neuronal cell models and assays.
- LEVEL III - Minimum of 5 years of hands-on experience with human iPSC-derived neuronal cell models and assays.
- Proficiency in cell-based assay techniques and fluorescence microscopy.
- Strong organizational and communication skills.
- Ability to work independently and collaboratively in a fast-paced research environment.
- Comfortable working with electronic lab notebooks.
Preferred Skills:
- Experience with CRISPR editing, RNA-seq, calcium imaging, high-content imaging, or complex co-culture systems is plus.
- Knowledge of automated liquid handling systems and high-throughput screening platforms.
- Familiarity with cardiometabolic diseases is a plus.
Applicant Notices & Disclaimers
- For information on benefits, equal opportunity employment, and location-specific applicant notices, click here
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position's pay range is $44.72/hr – $51.43/hr.